īenzodiazepines are generally safe and effective in the short term, although cognitive impairments and paradoxical effects such as aggression or behavioral disinhibition occasionally occur. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia longer-acting benzodiazepines are recommended for the treatment of anxiety. Benzodiazepines are categorized as either short-, intermediate- or long-acting. These properties make benzodiazepines useful in treating anxiety, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. īenzodiazepines enhance the effect of the neurotransmitter gamma-aminobutyric acid, which results in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, muscle relaxant and amnesic action. ![]() The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955, and made available in 1960 by Hoffmann–La Roche, which has also marketed diazepam (Valium) since 1963. A benzodiazepine ( Template:Pron-en, sometimes abbreviated to " benzo") is a psychoactive drug whose core chemical structure is the fusion of a benzene ring and a diazepine ring.
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